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Avodart dutasteride capsules ) and also on the effect of raloxifene bone mineral density and the risk of osteoporosis ( ). Finally, we Avodart buy online uk examined whether the decrease in incidence of osteopenia, as observed in the raloxifene group, was maintained after the discontinuation of treatment. Table 1 Raloxifene No. of men women Number cases osteopenia Total (%) of Serum concentrations testosterone Avodart 0.5mg $101.39 - $0.84 Per pill 683 10 577 (95% CI, 14.4–11.3) Serum concentrations of both testosterone and estradiol 815 9 831 10 (95% CI, 11.9–11.9) Total-to-free testosterone ratio 1.01 (0.60–1.77) 1.07 (0.73–1.58) 1.03 (0.70–1.52) Free testosterone (pg/ml) 4.0 ± 2.8 8.1 2.1 8.7 2.5 (95% CI, 7.8–8.3) Free estrogen (pg/ml) 1.9 ± 0.7 2.0 0.8 2.5 (95% CI, 1.8–2.2) Open in a separate window The incidence of osteopenia was significantly greater in the raloxifene group (6.1% vs. 3.2%; odds ratio [OR], 1.27; 95% CI, 1.06–1.50), as was the incidence of osteoporosis (3.3% vs. 2.2%; OR, 1.35; 95% generic form of avodart CI, 1.16–1.61). In the men who were not receiving raloxifene, bone mineral density decreased by 0.5% (95% CI, −0.7 to −0.3%; P =.002) and 1.5% (95% CI, −1.8 to −0.6%; P =.05) in the raloxifene and placebo groups, respectively, as compared with the men who received raloxifene. Serum concentrations cheap generic avodart of testosterone and estradiol declined by less in the raloxifene group (1.6 ± 0.3 vs. 3.7 0.5 pg/ml in the placebo group [P for trend =.05]), while free testosterone declined by less in the raloxifene group (0.97 ± 0.2 vs. 4.2 0.5 pg/ml in the placebo group [P =.02]). We conducted a subset analysis to examine whether men who had previously received raloxifene and were no longer taking the drug (n = 20) were less likely to present with osteopenia and osteoporosis than the men who had never received raloxifene (n = 21) ( ). We found a statistically significant difference in the incidence of osteoporosis between men who had previously received raloxifene and those who were no longer taking the drug (P =.05). However, the incidence of osteopenia was no longer statistically significant after the discontinuation of treatment. incidence osteoporosis was also no longer statistically significant in the men who had previously received raloxifene (P =.06), but the incidence of osteopenia was. bone mineral density decrease was statistically significant in the men who had previously received raloxifene (P <.001), but not in the men who had not previously received the drug (P =.11). Table 2 No raloxifene + bone mineral density decrease No raloxifene + osteopenia effect Number of cases Percent change in bone mineral density those not receiving raloxifene Placebo (n = 21) No raloxifene + bone mineral density decrease No raloxifene + osteopenia effect bone mineral density decrease No raloxifene + osteopenia effect Number of cases Percent change in bone mineral density those not receiving raloxifene Placebo (n = 21) No raloxifene + bone mineral density decrease No raloxifene + osteopenia effect bone mineral density decrease No raloxifene + osteopenia effect Open in a separate window The incidence of low bone mineral density and fracture was significantly greater in the men who were taking raloxifene (1.5% vs. 0.7%; OR, 2.19; 95% CI, 1.15–4.06); however, the incidence of low bone mineral density was not statistically significant in.
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